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This study was performed to evaluate the subacute toxicity of CJ-50002 (Vibrio vaccine) In SPF Spraque-Dawley (SD) rats. Vibrio vaccine was administered orally at a dose level of high (167 mg/ kg /day), medium (16.7 mg/kg/day), and low (1.67 mg/kg/day) once a day and repeated for 4 weeks. Ten males and female rats were assigned to each group. After 4 week administration, no significant dosedependent changes in body weight, water and food consumption rate or organ weight were noted among 4 groups. Urinanalysis, hematology, and serum chemistry, also fail to detect any dose-related change among 4 groups tested. During necropsy and histopathological examination, no specfc toxicity related to treated material was found. The results of this study demonstrated that vibrio vaccine when administered orally for 4 weeks at a high dose of 167 mg/kg/day, no dose-related toxicity was found in treated male and female rats.
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